Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor Signaling

Ron C.J. Schackmann,Sjoerd Klarenbeek,Eva J. Vlug,Suzan Stelloo,Miranda van Amersfoort,Milou Tenhagen,Tanya M. Braumuller,Jeroen Vermeulen,Petra van der Groep,Ton Peeters,Elsken van der Wall,Paul J. van Diest,Jos Jonkers,Patrick W. B. Derksen

Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor Signaling

2013

Ron C.J. Schackmann
Sjoerd Klarenbeek
Eva J. Vlug
Suzan Stelloo
Miranda van Amersfoort
Milou Tenhagen
Tanya M. Braumuller
Jeroen Vermeulen
Petra van der Groep
Ton Peeters
Elsken van der Wall
Paul J. van Diest
Jos Jonkers
Patrick W. B. Derksen

Based on conditional mouse models of metastatic breast cancer that are immunocompetent and clinically relevant, the current study provides an alternate rationale for therapeutic intervention of p120-catenin negative invasive breast cancer.

Keywords:

Breast cancer
Oncology
Anoikis
Immunology
Metastatic breast cancer
Growth factor receptor
Medicine
P120-catenin
Internal medicine
anoikis resistance

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