Mitochondrial potassium channels: From pharmacology to function

Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca 2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive oxygen species. In this paper, we describe the pharmacological properties of mitochondrial potassium channels and their modulation by channel inhibitors and potassium channel openers. We also discuss potential side effects of these substances. © 2006 Elsevier B.V. All rights reserved.