Phytochemical and Antimicrobial Studies of Pachypodium Lamerei
2021
Five compounds were reported for the first time in the tribe Malouetieae from the leaves and stems of
Pachypodium lamerei viz., fatty acid methyl ester (stearic acid methyl ester 1), a mixture of two steroidal
aglycones (β-sitosterol 2 and stigmasterol 3), a pentacyclic triterpene (ursolic acid 4) and a steroidal
glucoside (β-sitosterol-3-O-β-D-glucopyranoside 5). The structure elucidation was based on
comparison of their physical, chemical, chromatographic properties, spectral data with literature as well
as direct comparison with authentic compounds. The petroleum ether fraction and the total ethanolic
extract of (leaves and stems) exhibited minimum inhibitory concentrations (MICs) against
Pseudomonas aeruginosa (1.06 and 2.52 μg/ml), respectively. These results are comparable to that
obtained by amikacin (MIC, 2.38 μg/ml). Moreover, the petroleum ether fraction displayed the lowest MIC
(16.45 μg/ml) against Candida albicans. This result is greatly promising since the standard drug
(ketoconazole) exhibited MIC (185.87 μg/ml). This is the first time to estimate both antibacterial and
antifungal activities of any of Pachypodium species.
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