Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

Letteria Minutoli,Salvatore Arena,Giulio Bonvissuto,Alessandra Bitto,Francesca Polito,Natasha Irrera,Francesco Arena,Eugenia Fragalà,Carmelo Romeo,Piero Antonio Nicotina,Carmine Fazzari,Herbert Marini,Alessandra Implatini,Silvia Grimaldi,Noemi Cantone,Vincenzo Di Benedetto,Francesco Squadrito,Domenica Altavilla,Giuseppe Morgia

Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

2011

Letteria Minutoli
Salvatore Arena
Giulio Bonvissuto
Alessandra Bitto
Francesca Polito
Natasha Irrera
Francesco Arena
Eugenia Fragalà
Carmelo Romeo
Piero Antonio Nicotina
Carmine Fazzari
Herbert Marini
Alessandra Implatini
Silvia Grimaldi
Noemi Cantone
Vincenzo Di Benedetto
Francesco Squadrito
Domenica Altavilla
Giuseppe Morgia

In rat experimental varicocele, polydeoxyribonucleotide (PDRN) induces vascular endothelial growth factor (VEGF) production, thereby enhancing testicular function. This may point to a new therapeutic approach in human varicocele.

Keywords:

Vascular endothelial growth factor A
Adenosine A2A receptor
Adenosine receptor
Adenosine
Vascular endothelial growth factor
Varicocele
Endocrinology
Apoptosis
Medicine
Receptor
Internal medicine
Downregulation and upregulation
Testicle

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