Monomers for Oligonucleotide Synthesis with Linkers Carrying Reactive Residues: II. The Synthesis of Phosphoamidites on the Basis of Uridine and Cytosine and Containing a Linker with Methoxyoxalamide Groups in Position 2′

Svetlana V. Vasileva,T. V. Abramova,T. M. Ivanova,G. V. Shishkin,Vladimir N. Silnikov

Monomers for Oligonucleotide Synthesis with Linkers Carrying Reactive Residues: II. The Synthesis of Phosphoamidites on the Basis of Uridine and Cytosine and Containing a Linker with Methoxyoxalamide Groups in Position 2′

2004

Svetlana V. Vasileva
T. V. Abramova
T. M. Ivanova
G. V. Shishkin
Vladimir N. Silnikov

A convenient preparative synthesis of 2′-amino-2′-deoxyuridine was developed. Starting from 2′-amino-2′-deoxyuridine and 2′-amino-2′-deoxycytidine, monomers for the phosphoamidite oligonucleotide synthesis were obtained that carry a linker with methoxyoxalamide groups in position 2′.

Keywords:

Linker
Uridine
Cytosine
Oligonucleotide synthesis
Chemistry
Monomer
Biochemistry
Organic chemistry
Bioorganic chemistry
modified nucleosides
Stereochemistry

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