The effect of dealuminated jellyfish in mitigating toxicity on mice exposed to aluminum

Abstract In the present study, the removal effect of dealuminated jellyfish on Aluminum (Al) in mice was evaluated. The results showed that the consumption of dealuminated jellyfish significantly decreased Al accumulation in the liver of mice, indicating an Al-removing effect of dealuminated jellyfish on Al-enriched mice. In addition, the effect of dealuminated jellyfish consumption on an Al-overload model was further evaluated. The result showed that the Al content in different tissues and organs of mice was significantly reduced, but it had no significant effect on the other metallic element content. These results indicated that the samples from oral administration have a certain Al-removing effect in Al-overloaded mice. Moreover, the cluster analysis of differentially expressed proteins in blood and liver showed that a high dose of dealuminated jellyfish improve the expression of amine oxidase B and enhance the effect of Al discharge.