Transluminal Preparation of Aortic Dissection and CT and MR Manifestations:an in Vitro Experiment

Objective To explore the experience with transluminal preparation of aortic dissection in vitro and thus provide the basis for in vivo experiment.Methods Extracorporeal circulation was established with peristaltic pump in 40 isolated canine aortas.The aortic pressure ranged from 100 to 110 mmHg.The descending aortic wall was injured by metal hook through iliac artery approach,and the intimal injury was found with 5F catheter and guide wire through the innominate artery.The aortic intima was torn to establish the aortic dissection.After the establishment of aortic dissection,CT and MR were performed to observe the morphological characteristics of the aortic dissection.Results Among 40 aortas,aortic dissection was successfully established in 25 aortas,with the success rate of 62.5%.CT images showed that the injured aortic wall was thinner than normal aortic wall,and the double-barreled arotic dissection and the true lumen collapse were observed.MR images showed the low-intensity signal in both the true and false lumens,high-intensity signal in intimal flap,and high-intesity signal interrupted at the intimal tear.Conclusion The success rate of transluminal preparation of aortic dissection in vitro is high,and the CT and MR images are similar to those in human aortic dissection.This technique may be helpful in animal experiment in vivo.