Hypersensitivity to Procarbazine and Severe RSV Pneumonia in a Child with Hodgkin's Lymphoma

Herein we report respiratory syncytial virus (RSV) pneumonia in a child who had hypersensitivity to procarbazine. Urticarial plaques, maculopapular rash occurred in a child with Hodgkin's lymphoma while receiving procarbazine. Clinical improve- ment was achieved by withdrawal of procarbazine, administration of corticosteroids, diphenhydramine. After receiving the next course with bleomycin containing chemotherapy, RSV pneumonia developed which required prolonged mechanical ventilation and was treated with oral ribavirin. Hypersensitivity to procarbazine can be a life treating condition. Omitting pro- carbazine may be necessary. Respiratory syncytial virus pneumonia in the setting of both immunsupression and procarba- zine / bleomycin toxicity may have a more serious course.