Overexpression of WNT2 and TSG101 genes in colorectal carcinoma
2008
Colorectal carcinoma (CRC) arises as a result of mutational activation of oncogenes
coupled with inactivation of tumour suppressor genes. Mutations in APC, K-ras and p53 have
been commonly reported. In a previous study by our group, the tumour susceptibility gene 101
(TSG101) were found to be persistently upregulated in CRC cases. TSG101 was reported to be
closely related to cancers of the breast, brain and colon, and its overexpression in human papillary
thyroid carcinomas and ovarian carcinomas had previously been reported. The wingless-type
MMTV integration site family member 2 (WNT2) is potentially important in the Wnt/β-catenin
pathway and upregulation of WNT2 is not uncommon in human cancers. In this study, we report
the investigation for mutation(s) and expression pattern(s) of WNT2 and TSG101, in an effort to
further understand their role(s) in CRC tumourigenesis. Our results revealed no mutation in these
genes, despite their persistent upregulation in CRC cases studied.
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