Whole-transcriptome gene expression profiling in an epidermolysis bullosa simplex Dowling-Meara model keratinocyte cell line uncovered novel, potential therapeutic targets and affected pathways.

Julia Herzog,Raphaela Rid,Martin Wagner,Harald Hundsberger,Andreas Eger,Johann W. Bauer,Kamil Önder

Whole-transcriptome gene expression profiling in an epidermolysis bullosa simplex Dowling-Meara model keratinocyte cell line uncovered novel, potential therapeutic targets and affected pathways.

2015

Julia Herzog
Raphaela Rid
Martin Wagner
Harald Hundsberger
Andreas Eger
Johann W. Bauer
Kamil Önder

Background To be able to develop effective therapeutics for epidermolysis bullosa simplex (EBS), it is necessary to elucidate the molecular pathomechanisms that give rise to the disease’s characteristic severe skin-blistering phenotype.

Keywords:

Keratinocyte
Gene expression profiling
Genetics
Phenotype
Epidermolysis bullosa simplex
Signal transduction
Transcriptome
Cell culture
Biology
Mutation

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