Serum ferritin and iron in diabetic and non-diabetic with acute myocardial infarction

An increased serum ferritin level is presented as a risk factor for coronary artery disease. The role of diabetes mellitus on serum ferritin levels in myocardial infarction has recently been investigated. the present study has been carried out to investigate Comparison of the level of ferritin and iron in type 2 diabetic and nondiabetic patients with acute myocardial infarction(AMI).This case-control study has been conducted on 200 type 2 diabetic and non- diabetic patients with AMI. Blood samples were prepared and analyzed for the comparison of serum ferritin and iron, TIBC, CBC and blood lipids between the two groups. Female gender (OR=6.68) and smoking (OR=4.03) has been found to be significantly related to diabetes (OR=4.03). The mean ferritin level was 171.20 (SD=114.35) ng/dl in the case and 168.80 (SD=124.36) ng/dl in the control group (p=0.8), and the mean iron level was 87.71 (SD=35.58) mg/dl in the case and 62.70 (SD=22.27) mg/dl in the control group (p<0.0001, OR=1.86). Blood iron and ferritin levels were lower than the standard levels in both genders of patients with myocardial infarction (p<0.0001). Regarding the results of the present study, high blood ferritin level does not bring about type 2 diabetes, and the hypothesis of ferritin level association with type 2 diabetes and its elevated level in patients with AMI has not been confirmed; high levels of iron, on the other hand, may underlie development of type 2 diabetes; therefore, further investigation seems to be necessary in this regard. (Hamid Sharif Nia, Ali Akbar Haghdoost, Yiong Huak Chan, Mohammad Taghi Salehi Omran, Abolfazl Hashemi, Babak Alaei, Mohammad Ali Soleimani, Abolghasem Siyadat Panah and Fariba Tabari. Serum ferritin in diabetic and non-diabetic with acute myocardial infarction. Life Sci J 2012;9(4):2740-2745). (ISSN: 1097- 8135). http://www.lifesciencesite.com. 403