Comparative study of Salmonella typhimurium strains of various origins in murine models of enteral and intranasal infection

: Antibiotic-resistant S. typhimurium strains of different origin (isolated from patients in cases of hospital infections and enteral toxico-infections, as well as from water), when studied in experimental enteral and intranasal infection of mice showed, in comparison with antibiotic-sensitive strains, less pronounced lethal action and, accordingly, lower capacity for reproduction in the organs of the reticulo-endothelial system of mice. Multiresistant strains isolated from humans in enteral toxico-infections kill orally infected mice more frequently than strains isolated in hospital infections.