The use of ELM and MnM servers for the prediction of RANK functionin osteoclast formation

Osteoporosis is a skeletal disorder which weakens the bones and increases the risk of the bone cracking. There are many factors included in the pathogenesis of osteoporosis and a lot of them still remain unknown. The RANK/RANKL system is involved in osteoclast maturation. By binding to its receptor (RANK), RANKL stimulates osteoclast precursors to develop into fully mature osteoclasts. RANK transmits biochemical signals after the recruitment of the intracellular adaptor TNF receptor associated factor (TRAF) proteins. TRAF6 binds to RANK and plays an essential role in RANKL-mediated NF-κβ activation in transfected cell systems.