Galactose-mediated oridonin albumin nanoparticle and preparation method thereof

The present invention discloses a galactose-mediated oridonin albumin nanoparticles made from raw materials and auxiliary materials, raw materials for Rubescensine, accessories for galactosylated albumin, a crosslinking agent, frozen dry protecting agent and water, wherein the amount of raw materials and auxiliary materials prepared as follows: in terms 10ml nanoparticle formulation, Rubescensine 2.0mg ~ 40.0mg, galactosylated albumin 50.0 ~ 400.0mg, crosslinkers 0.4 ~ 8.4mg, lyoprotectant 0 or 0.1 ~ 0.5g, balance water. Galactose-mediated invention oridonin albumin nanoparticles, good biocompatibility, nanoparticles made injectable solutions help to increase the bioavailability of the drug, reduced dose, reduced toxicity, change the drug distribution can be achieved in vivo, to extend the time of drug action, the purpose of improving bioavailability. Preparation method is simple and suitable for mass production.