Synthesis and anti-microbial activity of ( Z)-4-(4-substituted-thiazol-2-yl)-1-(2- oxoindolin-3-ylidene) semicarbazide and its derivatives †

3-[(2S)-3-Acetyl-5-amino-N-(4-substituted-thiazol-2-yl)2,3-dihydro-1,3,4-oxadiazol-2-yl]-indolin-2-yl acetates, 1-{N-[(2R)-2-(-2-oxoindolin-3-ylidene)-4-oxo-1,3-thiazolidin-3-yl]-3-(4-substituted-thiazol-2yl)ureas, N-(4-substituted-thiazol-2-yl)-[1,3,4]-oxadiazino[6,5]indol-3-amines and (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxo-1-(substituted) methyl)indolin-3-ylidene)semicarbazides have been prepared by making use of (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxoindolin-3-ylidene) semicarbazides obtained by the reaction of (4-substituted thiazole-2-yl) semicarbazides and isatin. The structures of the newly synthesized compounds have been confirmed on the basis of analytical, IR, 1 H NMR and mass spectral data. The newly synthesized compounds have been screened for their antimicrobial activities.