Abstract 10291: Predictive Values of N-Terminal Pro-B-Type Natriuretic Peptide and Cardiac Troponin I for Myocardial Fibrosis in Hypertrophic Obstructive Cardiomyopathy

Background: Myocardial fibrosis, as a hallmark of hypertrophic cardiomyopathy (HCM), can be detected by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). The combination of high-sensitivity cardiac troponin T (hs-cTnT) and B-type natriuretic peptide (BNP) has been suggested useful in detecting myocardial fibrosis in patients with non-obstructive HCM. However, the values of those biomarkers to predict myocardial fibrosis in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. Hypothesis: We assessed the hypothesis that circulating levels of N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and cardiac troponin I (cTnI) may predict LGE in patients with HOCM. Methods: Patients with HOCM (n=163; age=47.2 ± 10.8, [range 20 to 71] years; 38.7% females) underwent peripheral venous sampling to determine concentrations of NT-proBNP and cTnI. Contrast-enhanced CMR was performed to identify and quantify myocardial fibrosis. We evaluated the relation between LGE and levels of NT...