P2-250 Omega 3 polyunsaturated fatty acids (PUFAs) and risk of early onset prostate cancer

Introduction In the UK, approximately 11% of newly registered PrCa cases are under the age of 60 years. The unequal incidence across different countries suggests that modifiable factors, such as dietary intake of omega 3 polyunsaturated fatty acids (PUFAs) may be important. Methods Data were analysed on 805 cases and 1283 controls of age Results For the highest compared with the lowest quartile of intake, total omega 3 dietary intake (OR=0.68, 95% CI 0.40 to 1.15, p=0.14), DHA (OR=0.71, 95% CI 0.48 to 1.05, p=0.09) and EPA (OR=0.72, 95% CI 0.46 to 1.14, p=0.16), all showed non-significant trends with decreased PrCa risk. However, increased supplement dosage of DHA and EPA both showed significant, protective dose-response relationships (p for trends=0.04). Conclusion This study of early onset prostate cancer has shown protective trends for supplement intakes of DHA and EPA which if confirmed in other studies could have implications for prevention.