Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis

During mitosis, store-operated Ca2+ entry (SOCE) is suppressed. Translocation of the ER Ca2+ sensor STIM1 to the plasma membrane is critical to SOCE activation, but in mitotic cells STIM1 is phosphorylated and fails to rearrange into near-plasma membrane puncta. Mutation of mitosis-specific phosphorylation sites rescues mitotic SOCE.