A Strategy toward the Biomimetic Synthesis of (±)-Morusalbanol A Pentamethyl Ether
2016
A strategy toward the biomimetic synthesis of morusalbanol A pentamethyl ether is described. The synthesis is based on a hydrogen-bond-assisted Diels–Alder cycloaddition between a dehydroprenyl diene and a chalcone dienophile. Selective cleavage of the ortho -methyl ether of the resulting cycloadduct allows rotation of the C3–C21 bond and subsequent intramolecular cyclization affords the pentamethyl ether of (±)-morusalbanol A. As with the natural product, morusalbanol A, a number of key proton and carbon signals are absent in the NMR spectra of the title product.
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