Properties of novel oligonucleotide analogues containing an acyclic nucleoside and a carbamate linkage

Satoshi Obika,Yoshihiro Takashima,Yasuhide Matsumoto,Atsuko Shimoyama,Yasuo Koishihara,Yoshiyuki Ohsugi,Takefumi Doi,Takeshi Imanishi

Properties of novel oligonucleotide analogues containing an acyclic nucleoside and a carbamate linkage

1996

Satoshi Obika
Yoshihiro Takashima
Yasuhide Matsumoto
Atsuko Shimoyama
Yasuo Koishihara
Yoshiyuki Ohsugi
Takefumi Doi
Takeshi Imanishi

Abstract Novel heterodimers containing an acyclic nucleoside and a carbamate linkage were incorporated into oligonucleotides, and the melting temperatures of the DNA-DNA and DNA-RNA duplexes as well as the nuclease resistance of the modified oligonucleotides were studied.

Keywords:

Oligonucleotide
Nucleoside
Organic chemistry
Biochemistry
Chemistry
Carbamate
Nuclease
acyclic nucleoside

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