Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial Dysplasia

Oral lichen planus (OLP) is the most common noninfectious oral disease and is considered a potentially malignant disorders (OPMDs). The etiology and pathogenesis of OLP are not completely understood and the malignant transformation remains under discussion. The aim was to asses the cytological and histological features of OLP, and establish relationship between clinical and microscopic profiles. A total of 10 patients diagnosed with OLP were investigated. Slides were prepared and stained with Hematoxylin­Eosin to identify 8 histological features and 8 cytological alterations. Finally, oral epithelial dysplasia degree was determined. Hyperplasia and loss of polarity of basal cells were detected in 90 % of cases. Anisonucleosis, nuclear pleomorphism and hyperchromasia affected 100 % of the sample. Six cases were classified as mild-grade OED, with no cases of severe-grade. Microscopic alterations were higher in women (P El liquen plano oral (LPO) es la enfermedad no infecciosa mas comun y se considera un trastorno potencialmente maligno. La etiologia y la patogenesis del LPO no se conoce y la transformacion maligna sigue siendo objeto de debate. El objetivo de este estudio fue evaluar las caracteristicas citologicas e histologicas del LPO y establecer la relacion entre los perfiles clinicos y microscopicos. Un total de 10 pacientes diagnosticados con LPO fueron investigados. Secciones histologicas se prepararon y tineron con hematoxilina-eosina para identificar 8 caracteristicas histologicas y 8 alteraciones citologicas. Finalmente, se determino el grado de displasia epitelial. La hiperplasia y la perdida de la polaridad de las celulas basales se detectaron en el 90 % de los casos. Anisonucleosis, pleomorfismo nuclear e hipercromasia afectaron al 100 % de las muestras. Seis casos fueron clasificados como displasia epitelial oral (DEO) de grado leve y no se reportaron casos de grado severo. Las alteraciones microscopicas fueron mayores en las mujeres (p