History of prostate biopsy – part 2

The major limitations of the transrectal ultrasound (TRUS) guided prostate biopsy (PBx) protocols are the risk of profound sepsis and the risk of persistently significant false negative rates, related to the under sampling of the anterior and apical prostate. To address these limitations, transperineal (TP) PBx has had a resurgence in routine clinical practice in the UK, ushering in the modern era of PBx.