CHIRAL SALEN-METAL COMPLEXES AS NOVEL CATALYSTS FOR ASYMMETRIC PHASE TRANSFER ALKYLATIONS
1999
Abstract Chiral, salen-metal complexes have been tested as catalysts for the C -alkylation of aldimine Schiff's bases of alanine esters with alkyl bromides under phase-transfer conditions (solid sodium hydroxide, toluene, ambient temperature, 1–10% of the catalyst). The best catalyst, which was derived from a Cu(II) complex of (1 R ,2 R or 1 S ,2 S )-[ N,N′ -bis(2′-hydroxybenzylidene)]-1,2-diaminocyclohexane, gave α-methyl-α-amino acids with enantiomeric excesses of 70–96%.
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