Heterogeneity of programmed cell death-ligand 1 expression in lung cancer

sequenced the miRNA in these cells and found that cells with EMT memory have distinct miRNA profile compared to cells with transient EMT, suggesting that the epigenetic switch upon chronic IL-1b exposure leads to selective gene expression. These findings, for the first time, demonstrate a unique feature in chronic inflammation that allows cells to metastasize and eventually grow in distant organs, suggesting that these cells may serve as a reservoir for tumor metastasis and relapse. The intent of this study is to ultimately identify targets to intervene in preventing and treating metastatic behavior in lung cancer.