Method for producing 2'-trifluoromethyl group-substituted aromatic ketone
2015
The present invention relates to a method for producing a 2'-trifluoromethyl group-substituted aromatic ketone, wherein a 2-halogen substituted benzotrifluoride compound is reacted with magnesium metal, and converts into a Grignard reagent, and the Grignard reagent is reacted with an acid anhydride, and then subjected to hydrolysis to produce a 2'-trifluoromethyl group-substituted aromatic ketone. The method for producing a 2'-trifluoromethyl group-substituted aromatic ketone of the present invention is capable of producing a 2'-trifluoromethyl group-substituted aromatic ketone without using costly raw materials, by generating a Grignard reagent as an intermediate, and effectively reacting the Grignard reagent with an acid anhydride. A 2'-trifluoromethyl group-substituted aromatic ketone produced by the method for producing a 2'-trifluoromethyl group-substituted aromatic ketone of the present invention can be used as a fine chemical, a pharmaceutical/agrochemical raw material, a resin/plastic raw material, an electronics/information material, an optical material or the like.
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