The Research Progress of 1,25(OH)2D3 Effects on Cervical Cancer

Cervical cancer is one of common gynecological malignancies. In recent years, due to the rise of human papillomavirus (HPV) infection rates, the worsening of the human environment and other reasons, the incidence of cervical cancer showed a rapid increasing trend. Early cervical cancer is usually treated by surgery, while patients of advanced disease use surgery combining with radiotherapy and chemotherapy and other treatment options. But the chemotherapy drugs currently used in clinical practice have more serious toxicity, limiting its clinical application. Therefore, the search for drugs of new and few side effects is one of the directions of cancer research. Recent studies have found that 1,25(OH)2D3 has significant anti-tumor effect, and now its anti-tumor effects in cervical cancer and its application are reviewed, to provide new ideas and theoretical basis for the clinical treatment of cervical cancer.