Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling
2016
Using a chimaeric integrin α5 (where the tail is replaced by that of α2), Yun et al. show that in endothelial cells, integrin α5 interacts with the cAMP-specific phosphodiesterase PDE4D5 to reduce cAMP levels and inflammation both in vitro and in vivo.
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