Expression of neural cell adhesion molecule in renal cell carcinoma.
2012
Neural cell adhesion molecule (NCAM) is important for cell migration and it
could be expressed in some renal cell carcinoma (RCC). In recent decades, the
incidence of RCC has been steadily rising by 2-4% each year. In this study
NCAM expression and correlation with nuclear grade in different RCC were
analyzed. We analyzed NCAM expression on 7 different RCC cell lines and 32
different RCC by immunohistochemistry, immunofluorescence, Western blot and
FACS analysis. NCAM expression is detected in 6 cell lines and 16 RCC cases.
NCAM-140 kDa isoform is expressed in different RCC and RCC cell lines. NCAM
expression in non-invasive clear cell RCC is lower than in clear cell RCC
with high nuclear grade. Expression of NCAM is not exclusive for specific RCC
type, so NCAM can not be used as a specific diagnostic marker for RCC. NCAM
expression is in correlation with nuclear grade in clear cell RCC, suggesting
that NCAM expression is involved in aggressive behavior and metastatic
potential in RCC. [Acknowledgment. Projekat Ministarstva nauke Republike
Srbije, br. 175047]
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