Synthesis, characterization and pharmacological evaluation of novel Indole derivatives

Back ground: Indoles and their derivatives are common heterocyclic compounds in nature. The Indole ring system is an important structural component in many drugs. Objectives: The present study aims to synthesize novel Indole derivatives and the compounds were evaluated for their in vitro anti-microbial activity. Methods: Novel Indole derivatives were synthesized from indole-3-aldehyde and benzaldehyde. And they were evaluated in vitro anti-microbial activity by using cup plate method. Results: A series of newly synthesized compounds were characterized by physical data and IR spectra. The synthesized compounds were showed significant anti-microbial activity. Conclusion: The synthesized compounds exhibited good anti-microbial activity in comparison with standard drug streptomycin. These data present a series of new Indole compounds with potential therapeutic effects in microbial diseases.