ELECTROCHEMICAL CHARACTERIZATION OF NEW 1,5-BENZODIAZEPINE DERIVATIVES

ABSTRACT Cyclic voltammetry was used to study the electrochemical behavior of new 1,5-benzodiazepine derivatives on a glassy carbon electrode. Well-defined oxida-tion peaks were observed in DMSO. The Electrochemical response of the glassy carbon electrode was evaluated as function of the scan rate, showing that the electron transfer process for compound ( 5 ) and ( 6 ) resulted to be controlled by diffusion. Keywords: Cyclic voltammetry, 1,5 benzodiazepines, Diffusive behavior. e-mail: paola.jara@unab.cl 1. INTRODUCTION Benzodiazepines (BZP) are biologically active molecules widely used as analgesic, hypnotics, sedatives and antidepressants agents 1,2,3 . Among others, there are some differences between the pharmacological effects of 1,4 and 1,5-BZP, for the latter, therapeutic potential and lower incidence of side effects has been described 4 .In addition to the other electrochemically active groups present in BZP core, such as, nitro, N -oxide and carbonyl groups, the drugs bearing the 1,4-benzodiazepine core are characterized by the presence of a relatively easily reducible azomethine