Mo1297 Mode of Delivery in Inflammatory Bowel Disease Patients: A Population-Based Study

disease. The 5-, 10-, and 20-year actuarial risk of colectomy was 2.6%, 4%, and 5% respectively. Of note, 48 patients (75%) received a proctocolectomy with ileo-anal anastomosis, and 12 (25%) developed a chromic recurrent pouchitis. In addition, more than 80% of patients received maintenance therapy with mesalazine at least 1.6 gr/daily, and 43% of patients used combined oral and topical (1-2/week) maintenance therapy. Male sex (hazard ratio [HR] = 3.5; 95% confidence interval [CI] 1.5-5.5) and pancolitis (HR = 2.5; 95% CI 1.2-4.3) were predictive for EC, after adjustment for confounders. Age at diagnosis older than 40 yrs (HR = 2.5; 95% CI 1.4-3.8) and intolerance/inefficacy of thiopurines (HR = 3.1; 95% CI 1.45.1) were predictive of LC. Conclusions: Colectomy was rather infrequent in our cohort, being more often performed for chronically active disease. The incidence of cancer an dysplasia was also low, probably because the extensive use and adherence to mesalazine maintenance therapy. The introduction of anti-TNF-alpha therapy in the last five years have not changed this figure so far.