Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist.
1998
The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721, shows superior in vivo blockade of NK-1 receptor mediated responses.
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