A kind of synthetic method of Metformin hydrochloride

The invention discloses a kind of synthetic method of Metformin hydrochloride, comprise the following steps：（1）Salt-forming stage；（2）Steam salt phase；（3）The condensation stage.The present invention is used as solvent, small toxicity low relative to traditional handicraft solvent cost by the use of toluene and DMF；Solvent repeats to apply mechanically, and reduces the discharge of waste liquid, is easy to industrialized production, greatly reduces production cost and Environmental costs；It is no in course of reaction to use catalyst, and the reaction time is short, is effectively improved stability of the dicyandiamide in reaction system, reduces the generation of dicyandiamide side reaction, simplify purifying technique.