Stuay on the insulin resistance and islet β-cell function in sabjects with different status of glucose metabolism:from a Heilongjiang scenario

Homeostasis model assessment for insulin resistance and islet β-cell function were evaluated in 143 cases with impaired fasting glucose(IFG),333 cases impaired glucose tolerance(IGT),113 cases IFG+IGT,265 cases diabetes mellitus,and 2204 cases normal glucose regulation.Insulin resistance and islet β-cell function were getting deteriorated progressively from normal glucose regulation to diabetes mellitus[In(HOMA-IR):0.27±0.26,0.41±0.24,and 0.59±0.30;In(HOMA-β):2.00±0.27,1.94±0.22,and 1.76±0.30].IFG,IGT,and IFG+IGT seem to have different mechanisms of pathogenesis and may be prevented individually. Key words: Insulin resistance; β-cell function; Glucose metabolism