Oligopeptide-simulated CSP (Chiral Stationary Phase) and preparation method thereof

The invention provides an oligopeptide-simulated CSP (Chiral Stationary Phase) and a preparation method thereof. The oligopeptide-simulated CSP comprises a chiral selective agent, connecting arms and a carrier; the chiral selective agent is fixedly carried on the surface of the carrier through coating or covalent bond connection with a silane coupling agent; the connecting arms are the connectingarms of covalent bonds; and the carrier is silica gel and filler for chromatography. The preparation method of the oligopeptide-simulated CSP comprises the following steps of: (1) preparing 2-chloro-N-(S-1-phenylethyl) acetamide; (2) preparing 2-(S-1-phenylethylamine-yl)-N-(S-1-phenylethyl) acetamide; (3) preparing a secondary amine compound; (4) preparing a chiral monomer containing three chiralunits; and (5) preparing the CSP. The invention has the advantages that the prepared oligopeptide-simulated CSP has excellent stability and the potential of being applied to chiral analysis, quantitycontrol and production of an enantiomer; and the whole reaction route has high yield, and is easy to operate and convenient for industrialized application.