Comparison of effects of Tangmaikang and voglibose on reducing blood sugar in type I diabetic rat models

Objective:To compare the Chinese traditional medicines Tangmaikang with α-amylase inhibitor voglibose in the treatment for type Ⅰ diabetic rat models,and to determine whether it can be used as positive treatments drug.Methods:Type Ⅰ diabetic rat models were made by alloxan intraperitoneal injection with two times.Oral administration period sustained for 15 d,the fasting blood glucose was measured during the administration.Results:Compared with the control group,Tangmaikang was able to significantly reduce the blood sugar of rats(P0.05),otherwise,voglibose could significantly reduce the blood sugar(P0.05).Conclusion:During the administration,type Ⅰ diabetic rat models can maintain stability.Tangmaikang and voglibose can obviously reduce the blood sugar as positive control drug in the treatment of type Ⅰ diabetic rat models.