ANTIVIRAL ACTIVITY OF MACROCYCLIC POLYETHERS AND THEIR COMPLEXES WITH THE ALKALINE METAL SALTS OF N-PHOSPHORYLATED AMIDES AND THIOAMIDES

We have previously shown that N-phosphorylated amides and thioamides and their alkaline metal salts have significant antiviral activity against influenza A (H3N2) virus [2]. Phosphorus-containing crown ether derivatives, including complexes of the alkaline metal salts of N-phosphorylated (thio)amides with crown ethers [3] also have potential as new antiviral agents. As part of our ongoing studies [2, 3], we have investigated the toxicity and antiviral properties of a series of Soviet-produced, commercially-available macrocyclic polyethers (I-VI), alkaline metal salts of N-phosphorylated thioamides (VII, VIII), and complexes of crown ethers with the alkaline metal salts of N-phosphorylated amides and thioamides (IX-XII).