Novel Method for the Synthesis of 3′,4′‐Dideoxygenated Pyranmycin and Kanamycin Compounds, and Studies of Their Antibacterial Activity Against Aminoglycoside‐Resistant Bacteria
2005
A novel protocol for converting a trans‐diol to an alkene under mild conditions was developed. This method led to the synthesis of a 3′,4′‐dideoxykanamycin (dibekacin) analog and a 3′,4′‐dideoxypyranmycin that were found to be active against aminoglycoside‐resistant bacteria.
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