A Nucleotide and Nucleosides Mixture Solution Improves Recovery of Energy Metabolism after Hepatic Ischemia in Rats

Hepatic ischemia/reperfusion is a common problem encountered under many clinical conditions, and it occurs in a variety of surgical procedures. Possible consequences include liver failure and/or multi-organ system failure, both of which have high rates of morbidity and mortality.1,2 Efforts to minimize the extent of injury incurred during the ischemic period or to maximize reparative process following ischemia have importance for survival.3 In vivo 31P-nuclear magnetic resonance (NMR) spectroscopy has been used to follow the response of hepatic high-energy phosphates during hepatic ischemia/reperfusion.4 It measures the continuous changes of hepatic adenosine triphosphate (ATP) levels and their metabolites, and is an effective tool to evaluate the serial data in the individual following drug treatment.