Anti-aging and Anti-diabetes Effects of Aconitum pesudo-laeve var. erectum Extracts

Aconitum pesudo-laeve var erectum has been known to possess anti-inflammatory activity and modulate the intestinal immune system. In addition, it has traditionally been used for the treatment of water retention in the body. In this study, the anti-aging and anti-diabetes effects of water and ethanol extracts from Aconitum pesudo-laeve var. erectum were investigated. The activities of each extract were measured by antioxidant tests such as DPPH and ABTS radical scavenging activity, antioxidant protection factor (PF), TBARs content, and -amylase and -glucosidase inhibition activity assay. DPPH radical scavenging activity was found in over 50% of water and ethanol extracts at , , respectively. The ABTS radical scavenging activity of ethanol extract was % at in water, which was highest among the ethanol extract concentrations. PFs measured with -carotene-linoleate model systems were in the order of ethanol (1.49 PF at ) > ethanol (1.40 PF at ) > water (1.33 PF at ) > water (1.27 PF at ). TBARs content in ethanol extracts () was , which was lower than that of water extracts and other ethanol extract concentrations. The extracts also showed over 90% of -amylase inhibition and over 60% of -glucosidase inhibition ratio in water () and ethanol extracts (100~). These results suggest that Aconitum pesudo-laeve var. erectum extracts could be used as a cosmetic source and preventive agent for aging and diabetes.