Coronary thermodilution to assess flow reserve : validation in humans

Background-Guide wire-based simultaneous measurement of fractional flow reserve (FFR) and coronary flow reserve (CFR) is important to understand microvascular disease of the heart. The aim of this study was to investigate the feasibility of simultaneous measurement of FFR and CFR by one pressure-temperature sensor-tipped guide wire with the use of coronary thermodilution and to compare CFR by thermodilution (CFR thermo ) with simultaneously measured Doppler CFR (CFR Doppl ). Methods and Results-In 103 coronary arteries in 50 patients, a pressure-temperature sensor-tipped 0.014-inch floppy guide wire and a 0.014-inch Doppler guide wire were introduced. Both normal vessels and a wide range of stenotic vessels were included. With 3 mL of saline at room temperature used as an indicator, by hand-injection, thermodilution curves in the coronary artery were obtained in triplicate, both at baseline and at intravenous adenosine-induced maximum hyperemia. After adequate curve-fitting, CFR thermo was calculated from the ratio of inverse mean transit times and compared with CFR Doppl calculated by velocities at hyperemia and baseline. Adequate sets of thermodilution curves and corresponding CFR thermo could be obtained in 87% of the arteries versus 91% for Doppler CFR and 100% for FFR. CFR thermo correlated fairly well to CFR Doppl (CFR thermo =0.84 CFR Doppl +0.17; r=0.80; P 20% between both indexes were seen in a quarter of all arteries. Conclusions-This study shows the feasibility of simultaneous measurement of FFR (by coronary pressure) and CFR (by coronary thermodilution) in humans by one single guide wire in a practical and straightforward way and will facilitate assessment of microvascular disease.