Adoptive cell therapy using PD-1+ myeloma-reactive T cells eliminates established myeloma in mice
2017
Background
Adoptive cellular therapy (ACT) with cancer antigen-reactive T cells following lymphodepletive pre-conditioning has emerged as a potentially curative therapy for patients with advanced cancers. However, identification and enrichment of appropriate T cell subsets for cancer eradication remains a major challenge for hematologic cancers.
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