Interleukin-23 in early disease development in rheumatoid arthritis

Objectives: To investigate the levels of interleukin (IL)-23 in patients with early rheumatoid arthritis (eRA) and the effect of anti-tumour necrosis factor (anti-TNF)-α treatment on IL-23 levels.Method: Treatment-naive eRA patients from the OPERA cohort were included (n = 151). Patients were randomized to methotrexate (MTX) plus adalimumab (ADA; n = 75) or MTX plus placebo-ADA (PLA; n = 76). Plasma samples were obtained at baseline and at months 3, 6, and 12 together with values for C-reactive protein (CRP), the 28-joint Disease Activity Score based on CRP (DAS28CRP), scores on the Clinical Disease Activity Index (CDAI) and the Simplified Disease Activity Index (SDAI), visual analogue scale (VAS) for pain/fatigue/physician global and total Sharp/van der Heijde score (TSS). IL-23 was measured at each time point.Results: IL-23 levels decreased significantly in the ADA group from 20.6 pg/mL (IQR 13.1–32.7 pg/mL) at baseline to 18 pg/mL (IQR 7.2–25.0 pg/mL) at 12 months (p < 0.01). No significant decrease in...