Association between hepatic and systemic inflammation and localized stage II/III periodontitis in young males: The CHIEF Oral Health study.

AIM To clarify the role of systemic inflammation in the associations between hepatic inflammation and localized periodontitis, which were conflicting among races. MATERIALS AND METHODS The study included 1112 military personnel (males), aged 18-40 years, in Taiwan. Localized periodontitis was classified into healthy/stage I (n = 796) and stage II/III (n = 316) according to the 2017 criteria. Systemic and hepatic inflammation were defined by the greatest tertiles of blood leukocyte counts (7.51 × 103 /μl) and alanine aminotransferase (30 U/L), respectively. Multiple logistic regression analysis with adjustments for age, metabolic syndrome, betel nut consumption, and smoking were utilized to determine the associations. RESULTS There was a significant association between having a high systemic inflammation, whatever the hepatic inflammation severity, and the risk of having a localized stage II/III periodontitis (odds ratio [OR]: 1.62 [1.09-2.42] and 1.47 [1.00-2.15], respectively, for the presence of a high hepatic inflammation or not). However, no significant association was found among participants with low systemic inflammation, whatever the hepatic inflammation severity (OR: 1.31 [0.91-1.91]). CONCLUSIONS An association between hepatic inflammation and localized periodontitis in Taiwanese was observed only if systemic inflammation co-existed, possibly accounting for the racial difference in the association significantly reported in Japanese but not in non-Asian populations in prior studies.