Catalytic Materials Evaluated by Adsorption and Inactivation of Parainfluenza Virus and Cytotoxicity of Mammalian Cells

A novel method for inactivating viruses based on adsorption and catalysis principles with the goal of developing non-specialized materials to filtrate, adsorb and catalyze viruses is proposed. these materials would be useful to more effectively control severe acute respiratory syndrome (sars) in china. the parainfluenza virus (piv), which is very similar to sars coronavirus (sars-cov), was used in the adsorption and inactivation experiments, and the cytotoxic effects of the catalytic materials to mammalian cells were also investigated. the results of retardation and adsorption experiments on aerosol-type viruses are in agreement with those of dna adsorption and capillary electrophoresis tests. some materials could strongly adsorb the virus with 100% efficiency even after the third acute vibration in physiological saline. some materials exhibit an interesting effect to inactivate the virus in eluates when the latter occurred positive in hemagglutination test and negative in detection of viable virus with inoculation to chicken embryo. these results suggested that the viruses were inactivated or decomposed by the catalytic effects. the cell virulence evaluation suggested that the very low toxicity of some materials is helpful for their application in protective garments. the materials with the highest performance will be tested with sars-cov, and the results are expected soon.