Assessment of Sumatriptan on Sepsis-Induced Kidney injury in the Cecal Ligation and Puncture Mice Model.
2021
Sepsis is a severe systemic inflammatory response with high mortality rate
resulting from different microorganisms. Cytokines activation is essential for
the immune response, but in painful conditions like sepsis, cytokines act as a
double-edged sword and dysregulate immune response which is life-threatening
owing to multiple organ dysfunction. The abnormality in 5-HT function is
involved in pathological conditions like irritable bowel syndrome, inflammation,
myocardial ischemia, itch and renal injury. Sumatriptan, a
5-HT1B/1D agonist, has anti-inflammatory and
anti-oxidative stress effects on animal models. This study was aimed to assess
the effects of sumatriptan on kidney injury, the levels of pro-inflammatory
cytokines and the percentage of survival in (CLP)-induced sepsis were
examined. Cecal ligation and puncture (CLP) model was done on adult C57BL/6 male
mice to induce Polymicrobial sepsis. Sumatriptan was injected intraperitoneally
1 h after the sepsis induction by CLP at doses of 0.1, 0.3, and
1 mg/kg in 3 treatment groups. To study the effect of
sumatriptan on short-term survival, septic animals were detected 72 h
after CLP. Serum levels of TNF-α, IL-1β, IL-6 and IL-10 were
evaluated. To study sepsis-induced acute renal failure, kidney functional
biomarkers and histopathological alterations were evaluated. Sumatriptan (0.3 mg/kg) administration significantly enhanced
survival rate (P<0.01) compared to the CLP group. The beneficial effects
of sumatriptan were related to a significant decrease in the pro-inflammatory
cytokines and elevated level of IL-10. Sumatriptan presented protective effects
on kidney biomarkers and histopathology assay. Anti-inflammatory effects of sumatriptan lead to decrease mortality rate and
inflammatory cytokines in CLP induction sepsis in C57BL/6 mice.
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