EHMTI-0058. Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in an Iranian population

Results Allele V had significantly lower frequency in case group than control subjects (P=0.00, OR=0.25, CI=0.15 0.40). The frequency of migraine patients that were carrier of V allele (V/V and A/V) was statistically significant lower than control group (P=0.003, OR=2.39, CI: 1.35 4.23). There was no significant difference of alleles frequency between three grades of MIGSEV (P=0.316). Also total HIT-6 score was not significantly different between different genotypes (0.466). Conclusion In conclusion our results showed that Ala379Val gene polymorphism of Lp-PLA2 is associated with lower risk of migraine but not with severity of headaches. No conflict of interest.