Antidepressant Agents in Short Bowel Syndrome

Abstract Purpose This study aimed to determine whether short small intestine modifies antidepressant concentrations. Methods The C ss values and concentration–dose ratios (CDRs) of citalopram or escitalopram, administered orally or intravenously, were determined in patients with short bowel syndrome. Findings Eight patients (6 males and 2 females) were included in the study. High CDRs were obtained in orally treated patients with >180 cm of small bowel and in those with >80 cm of small bowel and 50% of colon. Three patients had low C ss values, including 1 patient who received intravenous treatment. Implications The variability of drug absorption and metabolism makes prescribing SSRIs challenging in these patients.