Synthesis of Heteroarylogous 1H-Indole-3-carboxamidines via a Three-Component Interrupted Ugi Reaction
2014
A novel one-pot multicomponent synthesis of heteroarylogous 1 H -indole-3-carboxamidines starting from readily available N -alkyl- N -(1 H -indol-2-ylmethyl)amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.
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