Efficacy of Ivabradine and Bisoprolol Based on the Results of Flow Mediated Dilation in Patients with Coronary Heart Disease

In this article, the possible application of Ivabradine and Bisoprolol in patients with stable angina based on the results of clinical and hemodynamic indices, Flow Mediated Dilation (FMD) and exercise loading tolerance (ELD) are discussed. In this study, 60 patients with stable angina II-III FC were included. Patients were randomized into two groups and given Bisoprolol and Ivabradine as the main treatment. Patients underwent a treadmill test by Bruce protocol and FMD probe by the Celermajer method. After 10—14 days of daily treatment, the patients were switched from one medicine to another, in both groups, and the results of FMD and ELD were analyzed. After treatment with Ivabradine, an increase in the chronotropic effect in the exercise tests was observed; however, the improved endothelial function, assessed by the results of the flow mediated dilation test was quite significant. IJBM 2011; 1(3):158-162. © 2011 International Medical Research and Development Corporation. All rights reserved.